Low atazanavir concentrations in cerebrospinal fluid
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چکیده
منابع مشابه
Effect of protein binding on unbound atazanavir and darunavir cerebrospinal fluid concentrations.
HIV-1 protease inhibitors (PIs) exhibit different protein binding affinities and achieve variable plasma and tissue concentrations. Degree of plasma protein binding may impact central nervous system penetration. This cross-sectional study assessed cerebrospinal fluid (CSF) unbound PI concentrations, HIV-1 RNA, and neopterin levels in subjects receiving either ritonavir-boosted darunavir (DRV), ...
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ژورنال
عنوان ژورنال: AIDS
سال: 2009
ISSN: 0269-9370
DOI: 10.1097/qad.0b013e328317a702